A Facile One-Pot Synthesis of New Poly Functionalized Pyrrolotriazoles via a Regioselective Multicomponent Cyclisation and Suzuki–Miyaura Coupling Reactions

The first access to N-1, N-4 disubstituted pyrrolo[2,3-d][1,2,3]triazoles is reported. series were generated using a “one-pot” MCR, leading single regioisomer of the attempted heteroaromatic skeleton in good yields. Next, functionalization C-5 and C-6 positions was investigated. (Het)aryl groups introduced at regioselective electrophilic brominations followed by Suzuki–Miyaura cross coupling reactions. Palladium-catalyzed cross-coupling conditions optimized representative library various boronic acids employed establish scope limitations method.